Games would be played in odd-number years on dates reserved for friendlies, starting after the 2018 World Cup.
No exact details have been confirmed, but there would be up to four divisions with promotion and relegation.
The 54 member associations of European football’s governing body will vote at its annual congress in Kazakhstan.
Uefa general secretary Gianni Infantino has confirmed to set up the new tournament should it be reached on Thursday.
He said: “What has triggered what is being called the Nations League is the international calendar and the dates for friendly matches.
“We have been looking at optimising the structure of the calendar without bringing in any more dates.
“There are teams everyone wants to play against and other teams who struggle to get the opponents they’d ideally like. For all national associations, the fact is that national team matches are key for their development.”
On rankings, England should be in the top division with the likes of Spain, Germany and Italy.
Each division will then be divided into groups with the winners qualifying for a semi-final and final.
While matches will be played on dates reserved for friendlies, there will still be flexibility for smaller countries to arrange high-profile fixtures with bigger European teams and for nations to play friendlies against national sides from outside Europe.
The Football Association are in favour of the plan, with chairman Greg Dyke saying this month: “The hard thing is the detail but I think a Nations League where we played the top nations would be very attractive.”
By Joshua Pritchard – @Josh_pritchard1 – https://twitter.com/Josh_pritchard1
