England meet Spain in a meaningless international encounter in Alicante on Friday evening – in what will be another tough test for Roy Hodgson’s young squad.
The Three Lions face the current European Championship holders in the first of two games, the second of which against France at Wembley next week, as England prepare for the Finals in France next summer.
The Spanish, who are managed by Vincente Del Bosque, have injury problems of their own, after La Roja finished top of their group for qualifying.
Del Bosque will be without Real Madrid trio, Isco, Dani Carvajal and skipper, Sergio Ramos, as well as Manchester City maestro, David Silva.
Un-capped forwards, Paco Alcacer and Nolito, who play for Valencia and Celta Vigo respectively, could make their international bows against England.
Premier League based players, Cesc Fabregas, Pedro, David De Gea, Juan Mata, Santi Cazorla and Diego Costa have all made the cut.
Predicted squad: Casillas: Gaspar, Pique, Bartra, Alba; Busquets, Fabregas, Iniesta, Thiago; Alcacer, Costa.
England have several players unavailable for the friendly game – Theo Walcott, Alex Oxlade-Chamberlain, Jack Wilshere and Danny Welbeck are all out of the fixture.
We already know that Roy Hodgson has decided to rest Wayne Rooney, while Jamie Vardy will also miss out, after picking up a knock for Leicester City last weekend.
Injuries mean that England could blood some of the younger players, who are set to be given game time over the next two international friendlies.
Joe Hart and Jack Butland will both be vying for a place in goal, while Tottenham youngsters Eric Dier and Dele Alli could start.
Staying with Spurs, and Harry Kane is likely to start up front on his own, given England’s striker crisis, alongside Raheem Sterling and Ross Barkley in support.
Predicted squad: Hart; Walker, Jones, Smalling, Bertrand; Carrick, Delph; Lallana, Barkley, Sterling; Kane.