United travel to the Netherlands to take on Feyenoord, still smarting from Saturday’s Derby Day defeat to neighbours City.
After that disappointment, Mourinho commented that any player who let him down in that game will not feature against the Dutch side.
And Wayne Rooney, Jesse Lingard, Henrikh Mkhitaryan, Luke Shaw and Antonio Valencia have all been left at home.
Phil Jones will not feature either, due to injury. Marcus Rashford is set for his first start of the season, and Ander Herrera could join him, after the pair both produced strong substitute performances on Saturday.