Home Football Top 10 most prolific strikers in the Premier League FootballPremier LeagueArsenalChelseaEvertonLiverpoolManchester CityManchester UnitedEnglandSouthamptonTottenham Top 10 most prolific strikers in the Premier League By Liam Chambers - Dec 19, 2016 5 0 FacebookTwitterPinterestWhatsApp 2) Sergio Aguero (Manchester City) 10 goals; 1008 minutes played; 101 minutes per goal